Dr. President Trump,Please accept my resig-nation, effective today.During my tenure, I an-nounced 50 major FDAreforms. Joe Biden’sFDA had none. I’m ex-tremely proud that wereduced drug reviewtimes from a year to 1-2months, wrote newguidance to advancepsychedelics, intro-duced a new “plausiblemechanism”pathwayfor rare disease drugs,and changed estrogenlabels to tell women thetruth about menopausalhormone replacement.It’s been the honor of alifetime to serve as yourFDA Commissioner. I amforever grateful.Respectfully,Marty Makary M.D.,M.P.H.